Which operation change has little impact on the safety and effectiveness of aerial application?

Moving to a different mixing loading location has little impact on the safety and effectiveness of aerial application because it primarily concerns where the chemicals are prepared and loaded onto the aircraft rather than how the application is conducted in the air. This operation change does not directly influence the flight dynamics, spray pattern, or application rates that are critical to ensuring effectiveness and safety in the aerial application process.

In contrast, changes that involve the pilot's experience, flight altitude, or the type of spray nozzle can significantly affect the application. For example, altering flight altitude can impact drift potential, coverage efficiency, and the likelihood of hitting the target area, while switching the spray nozzle affects droplet size and distribution, which are critical for effective application. Therefore, the mixing loading location is a logistical aspect that, while important for operational efficiency, does not have the same direct impact on aerial application safety and effectiveness.